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Team BIOMARQUEURS – Biomarkers of performances, adaptation and qualities

Team BIOMARQUEURS aims at identifying the metabolic and physiological mechanisms that control the plasticity of tissues determining ruminant productions, adaptive responses and efficiency, and designing phenotyping tools for product qualities and ruminant production traits. The objectives of the research are:

  • To identify the responses of ruminants to rearing practices or constraints, both at the animal and product levels;
  • To understand the metabolic and physiological mechanisms controlling product yield and qualities (carcasses, meat, milk), tissue plasticity (muscle, mammary gland, adipose tissue, liver), nutrient partitioning and adaptive responses (mainly metabolic, neuroendocrine or inflammatory responses);
  • To unravel molecular and cellular indicators (biomarkers) of product, tissue and ruminant trait variances through bioinformatics and mathematical analyses;
  • To propose tools to quantify these biomarkers and evaluate product qualities, ruminant performance and traits, as well as the trade-offs between these components contributing to animal efficiency.

 

BIOMARQUEURS conducts studies on ruminants as target species, and also on animal models (such as transgenic mice), and on cell/tissue cultures. It uses genomics (mainly transcriptomics, proteomics) to unravel mechanisms and biomarkers. More traditional analytical methods are used to phenotype nutritional (lipids, fatty acids and peroxidation products) and sensorial (evaluation panel) qualities of meat and milk, and whole body metabolism (plasma hormones, metabolites). Data processing (bioinformatics, databases, prediction and modelling) tools allow to establish relationships between molecular changes and phenotypes.

 

Contact: Muriel Bonnet


 

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